Yonsei Institute for Advanced Study

Low-intensity, low-frequency ultrasound (LILFU) is the next-generation, non-invasive brain stimulation technology for treating various neurological and psychiatric disorders. However, the underlying cellular and molecular mechanism of LILFU-induced neuromodulation has remained unknown. Here, we report that LILFU-induced neuromodulation is initiated by opening of TRPA1 channels in astrocytes. The Ca2+ entry through TRPA1 causes a release of gliotransmitters including glutamate through Best1 channels in astrocytes. The released glutamate activates NMDA receptors in neighboring neurons to elicit action potential firing. Our results reveal an unprecedented mechanism of LILFU-induced neuromodulation, involving TRPA1 as a unique sensor for LILFU and glutamate-releasing Best1 as a mediator of glia-neuron interaction. These discoveries should prove to be useful for optimization of human brain stimulation and ultrasonogenetic manipulations of TRPA1.

Metal halide perovskite nanocrystals with the chemically tunable bandgap and superb optical properties are promising candidates for a number of high performance optoelectronic and photonic applications....

Title:Opportunities and challenges in miniaturized implantable systems for clinical monitoring and neural interfacing for the brain Date: 2020.2.18, Tuesday, 3:30pm~ Venue: IBS Hall, Auditorium

Title: Spatiotemporal interrogation of molecular mechanobiology at the cell-cell signaling interface with nanotechnology tools Date: 2020.2.11, Tuesday, 3:30pm~ Venue: IBS Hall, Auditorium

Title: Development of mRNA polyplex micelles through engineering polymers and mRNA for in vivo therapeutic applications Date: 2020.1.10, 5:00pm~ Venue: IBS Hall, Auditorium

Date : 2019.12.16 (Monday) 3:30 pm Venue : IBS Hall, Auditorium Speaker: Prof. Mikhail G.Shapiro(Imaging & Bio-engineering of Caltech) Title: Talking to Cells: Bio Molecular Engineering for Nano-Invasive Imaging & Control of Cellular Function

Date: November 28, 11 am Venue: IBS Hall, Auditorium (610)

Date : 2019.11.8.(Friday), 3:30 pm Venue : IBS Hall, Auditorium Speaker: Director Hee-Sup Shin (IBS Center for Cognition & Sociality) Title: Understanding the mind through brain research(뇌 연구를 통한 마음의 이해)

Date: Monday Nov 4, 2019 Time: 1:00 pm @ Auditorium, IBS Hall Title: Soft electronics based on designer smart electromaterials and devices

Date: Tuesday Oct 15, 2019 Time: 3:30pm @ Auditorium, IBS Hall Title: Nano-engineered Particulate Systems for Disease Diagnosis and Therapy