Yonsei Advanced Science Institute

• Director
• Faculty & SAB
• Researchers & Students
• Administrative Staff

Faculty & SAB

• Professors
• SAB (Scientific Advisory Board)

• • Nanobiotechnology, Cell Engineering, Molecular & Cell Biology
  • Minsuk Kwak (곽민석)
  • minsuk.kwak@yonsei.ac.kr

Education

• 2011 - 2016Ph.D. in Biomedical Engineering, Yale University (Advisor: Rong Fan)
• 2007 - 2011B.S. in Bioengineering, Rice University

Professional Career

• 2020.9 - PresentAssistant Professor, Nano Biomedical Engineering, Advanced Science Institute, Yonsei University, Seoul, Korea
• 2017.1 - 2020.8Postdoctoral Fellowship, University of California, San Francisco (UCSF) (Advisor: Young-wook Jun)

Awards and Honors

• 2019Best Poster Award, ACS Publication & IBS Forum: Nanomaterials for Energy and Life Sciences
• 2018 - 2021Life Science Research Foundation (LSRF) Postdoctoral Research Fellowship
• 2018 - 2020American Association of Cancer Research (AACR) Lymphoma Research Postdoctoral Fellowship (declined)
• 2018 - 2019Burroughs Wellcome Fund 2018 Collaborative Research Travel Award
• 2015 - 2016Edward L. Barlow Fellowship, Department of Biomedical Engineering, Graduate School Tuition and Support, Yale University,
• 2007 - 2011Allen International Fellowship, Rice University, 4-year full university tuition and fee scholarship

Publications

Google Scholar Page

1. Lin M, Lee J-u, Kim Y, Kim G, Jung Y, Jo A, Park M, Lee S, Lah JD, Park J, Lee J-H, Kwak M, Lungerich D*, Cheon J*, “A magnetically-powered nanomachine with a DNA clutch”, Nature Nanotechnology, accepted and in press, (2023)

2. Shin W, Lee Y, Lim J, Lee Y, Lah JD, Lee S, Lee J-u, Yu R, Lee PH, Lee J-H, Kwak M*, Cheon J*, "Nanoscale magneto-mechanical-genetics of deep brain neurons reversing motor deficits in Parkinsonian mice", Nano Letters, 24 (1), 270-278 (2024), DOI: https://doi.org/10.1021/acs.nanolett.3c03899 (* co-corresponding authors)

3. Jeong S#, Shin W#, Park M, Lee JU, Lim Y, Noh K, Lee JH, Jun YW*, Kwak M*, Cheon J*, "Hydrogel magnetomechanical actuator (h-MMA) nanoparticles for wireless remote control of mechanosignaling in vivo", Nano Letters, 23(11): 5227–5235 (2023), DOI: https://doi.org/10.1021/acs.nanolett.3c01207 (* co-corresponding authors)

4. Kim W-S#, Min S#, Kim SK, Kang S, Davis H, Bar-Zion A, Malounda D, Kim YH, An S, Lee J-H, Bae SH, Lee JG, Kwak M, Cho S-W*, Shapiro MG*, Cheon J*, “Magneto-acoustic protein nanostructures for non-invasive imaging of tissue mechanics in vivo”, Nature Materials, (2023); DOI: https://doi.org/10.1038/s41563-023-01688-w

5. Kwak M^#, Southard KM^#, Kim WR, Lin A, Kim NH, Gopalappa R, Lee HJ, An M, Choi SH, Jung Y, Noh K, Farlow J, Geogakopoulos A, Robakis NK, Kang MK, Kutys ML, Seo D, Kim HH, Kim YH, Cheon J, Gartner Z*, Jun YW*, “Adherens junctions organize size-selective proteolytic hotspots critical for Notch signalling”, Nature Cell Biology, in press (2022); DOI: https://doi.org/10.1038/s41556-022-01031-6 (# co-first author)
   
   
6. Thach TT, Bae DH, Kim NH, Kang ES, Lee BS, Han K, Kwak M, Choi H, Nam J, Bae T, Suh M, Hur JK, Kim YH*, “Lipopeptide-based nanosome-mediated delivery of hyperaccurate CRISPR/Cas9 ribonucleoprotein for gene editing”, Small, 15, 1903172, (2019); DOI: https://doi.org/10.1002/smll.201903172
   
   
7. Kwak M^#, Gu W^#, Jeong H, Lee HJ, Lee JU, An M, Kim YH, Lee JH, Cheon J*, Jun YW*, “Small, clickable, and monovalent magnetofluorescent nanoparticles (MFNs) enable mechanogenetic regulation of receptors in a crowded live cell microenvironment”, Nano Letters, 19(6): 3761-3769, (2019); DOI: https://doi.org/10.1021/acs.nanolett.9b00891, (# co-first author)
   
   
8. Janiszewska M, Tabassum DP, Castano Z, Cristea S, Yamamoto KN, Kingston NL, Murphy KC, Shu S, Harper NW, Alcazar CGD, Aleckovic M, Ekram MB, Cohen O, Kwak M, Qin Y, Laszewski T, Luoma A, Marusyk A, Wucherpfennig KW, Wagle N, Fan R, Michor F, McAllister SS, Polyak K*, “Subclonal cooperation drives metastasis by modulating local and systemic immune microenvironments”, Nature Cell Biology, 21, 879-888, (2019); DOI: https://www.nature.com/articles/s41556-019-0346-x
   
   
9. Wang N, Zheng J, Chen Z, Liu Y, Dura B, Kwak M, Xavier-Ferrucia J, Lu YC, Roden C, Cheng J, Krauss D, Ding Y, Fan R, Lu J, “Single-cell microRNA/mRNA co-sequencing reveals non-genetic heterogeneity and novel regulatory mechanisms”, Nature Communication, 10(1): 95, (2018); DOI: https://www.nature.com/articles/s41467-018-07981-6
   
   
10. Huh SJ, Alcazar CR, Ekram MB, Trinh A, Liu LL, Beca F, Zi X, Kwak M, Bergholtz H, Su Y, Ding L, Russnes HG, Richardson AL, Babski K, Kim EMH, McDonnell III CH, Wagner J, Rowberry R, Freeman GJ, Deborah Dillon D, Sorlie T, Coussens LM, Garber JE, Bobolis K, Allred DC, Park SY, Fan R, Michor F, and Polyak K, “Immune escape in breast cancer during in situ to invasive carcinoma transition”, Cancer Discovery, 7(10):1098-1115, (2017); DOI: https://doi.org/10.1158/2159-8290.CD-17-0222
    
    
11. Jayatilaka H, Tyle P, Chen JJ, Kwak M, Ju JA, Kim HJ, Lee JSH, Wu PH, Fan R, Gilkes DM, Wirtz D, “Novel synergistic IL6/8 paracrine signaling pathway infers new strategy to inhibit tumor cell migration”, Nature Communications, 8, 15584, (2017); DOI: https://doi.org/10.1038/ncomms15584
    
    
12. Mao L, Chen J, Zhang X, Kwak M, Wu Y, Fan R, Zhang L, Pei J, Yuan G, Song C, Ge J, Ding W, “A promising biodegradable magnesium alloy suitable for clinical vascular stent application”, Scientific Reports, 7, 46343 (2017); DOI: https://doi.org/10.1038/srep46343
    
    
13. Chen JJ, Kwak M, Fan R, “Single-cell cytokine profiling to investigate cellular functional diversity in hematopoietic malignancies”, Methods in Molecular Biology, 1465:243-54, (2016); DOI: https://link.springer.com/protocol/10.1007/978-1-4939-4011-0_19
    
    
14. Kwak M^#, Han L^#, Chen JJ, Fan R, “Interfacing Inorganic Nanowire Arrays and Living Cells for Cellular Function Analysis”, Small, 11(42), 5600-10, (2015); DOI: https://doi.org/10.1002/smll.201501236 (# co-first author)
    
    
15. Kleppe M^#, Kwak M^#, Koppikar P, Riester M, Keller M, Bastian L, Hricik T, Bhagwat N, McKenney AS, Papalexi E, Abdel-Wahab O, Rampal R, Marubayashi S, Chen JJ, Romanet V, Fridman JS, Bromberg J, Teruya-Feldstein J, Murakami M, Radimerski T, Michor F, Fan R*, Levine RL*, “JAK-STAT Pathway Activation in Malignant and Nonmalignant Cells Contributes to MPN Pathogenesis and Therapeutic Response”, Cancer Discovery, 5(3): 316-313, (2015); DOI: https://doi.org/10.1158/2159-8290.CD-14-0736 (# co-first author)
    
    
16. Mao L, Shen L, Chen J, Wu Y, Kwak M, Lu Y, Xue Q, Pei J, Zhang L, Yuan G, Fan R, Ge J, Ding W, “Enhanced Bioactivity of Mg-Nd-Zn-Zr Alloy Achieved with Nanoscale MgF2 Surface for Vascular Stent Application”, ACS Applied Material and Interfaces, 7(9): 5320-5330, (2015); DOI: https://doi.org/10.1021/am5086885
    
    
17. Kwak M^#, Kim DJ, Lee MR, Wu Y, Han L, Lee SK, Fan R, “Nanowire Array Chips for Molecular Typing of Rare Trafficking Leukocytes with Application to Neurodegenerative Pathology”, Nanoscale, 6(12):6537-50, (2014); doi: https://doi.org/10.1039/C3NR06465D (# co-first author)
    
    
18. Lee SK, Kim DJ, Lee GH, Kim GS, Kwak M, Fan R, “Specific Rare Cell Capture Using Micro-patterned Silicon Nanowire Platform”, Biosensors and Bioelectronics, 54: 181-188, (2014); doi: 10.1016/j.bios.2013.10.048
    
    
19. Kwak M^#, Mu L, Lu Y, Chen JJ, Brower K, Fan R, “Single-cell Protein Secretomic Signatures as Potential Correlates to Tumor Cell Lineage Evolution and Cell-cell Interaction”, Frontiers in Oncology, 3(10), (2013); DOI: https://doi.org/10.3389/fonc.2013.00010 (# first author)
    
    
20. Lee SK, Kim GS, Wu Y, Kim DJ, Lu Y, Kwak M, Han L, Hyung JH, Seol JK, Sander C, Gonzalez A, Li J, Fan R, “Nanowire Substrate-based Laser Scanning Cytometry for Quantitation of Circulating Tumor Cells”, Nano Letters, 12(6): 2697-2704, (2012); DOI: https://doi.org/10.1021/nl2041707

 

 

 

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