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[Seminar] [Special Seminar] Prof. C. Justin Lee (IBS), 22/Jan/2021 "Ultrasonogenetic Neuromodulation via Astrocytic TRPA1" (Jan 22, 2021)

Low-intensity, low-frequency ultrasound (LILFU) is the next-generation, non-invasive brain stimulation technology for treating various neurological and psychiatric disorders. However, the underlying cellular and molecular mechanism of LILFU-induced neuromodulation has remained unknown. Here, we report that LILFU-induced neuromodulation is initiated by opening of TRPA1 channels in astrocytes. The Ca2+ entry through TRPA1 causes a release of gliotransmitters including glutamate through Best1 channels in astrocytes. The released glutamate activates NMDA receptors in neighboring neurons to elicit action potential firing. Our results reveal an unprecedented mechanism of LILFU-induced neuromodulation, involving TRPA1 as a unique sensor for LILFU and glutamate-releasing Best1 as a mediator of glia-neuron interaction. These discoveries should prove to be useful for optimization of human brain stimulation and ultrasonogenetic manipulations of TRPA1.

[Seminar] [Special Seminar] What can we gain from imposing strong quantum confinement on the perovskite nanostructures? (Dec 15, 2020)

Metal halide perovskite nanocrystals with the chemically tunable bandgap and superb optical properties are promising candidates for a number of high performance optoelectronic and photonic applications....

[Event] President of Yonsei University visited IBS CNM (Nov 5, 2020) Hot

On the 5th of November, 2020, the presidential delegation of Yonsei University, including Seoung Hwan Suh, the president visited IBS CNM. Jinwoo Choen, the director of IBS CNM greeted the delegation and gave a hall tour.

[SF@Y] SF@Y Season 3! "Create NANO" (Sep 18, 2020) Hot

Science Factory at Yonsei, Season 3, 2020 Summer

[YouTube] Interview: Dr. Daniel Rossi (Aug 27, 2020)

IBS CNM Researcher Interview (2)

[Event] The President of the IBS at IBS CNM (Aug 13, 2020) Hot

Do Young Noh, the President of the Institute for Basic Science (IBS) visited IBS CNM

[Event] IBS CNM with Institut Français Corée du Sud (Jul 28, 2020) Hot

Science and Higher Education Officers of French Embassy(Institut Français Corée du Sud) visited IBS CNM to share passionate ideas with us

[YouTube] Interview: Dr. Chang Yeol Lee (Jun 22, 2020) Hot

IBS CNM Researcher Interview (1)

[YouTube] IBS CNM & Nano BME Facility Introduction (Apr 17, 2020) Hot

Laboratory tour with students and researchers of IBS CNM & Nano BME

[YouTube] Interview: New students' Nano BME Life (Korean) (Apr 1, 2020) Hot

Interview with new students of 2020. Find out how they think about Nano BME life!


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