Yonsei Advanced Science Institute

• Research Areas
• Research Highlights
• Publications
• News Archive

Research Highlights

• [Nanobio Interface]   May 16, 2023
  Hydrogel Magnetomechanical Actuator Nanoparticles for Wireless Remote Control of Mechanosignaling In Vivo
  Sumin Jeong†, Wookjin Shin†, Mansoo Park, Jung-uk Lee, Yongjun Lim, Kunwoo Noh, Jae-Hyun Lee, Young-wook Jun*, Minsuk Kwak*, and Jinwoo Cheon* († equally contributed)
  Nano Lett., online published

  As a new enabling nanotechnology tool for wireless, target-specific, and long-distance stimulation o...

• [Precision Nanomedicine]   Feb 1, 2023
  CRISPR-Enhanced Hydrogel Microparticles for Multiplexed Detection of Nucleic Acids
  Yoon Ho Roh†, Chang Yeol Lee†, Sujin Lee, Hyunho Kim, Amy Ly, Cesar M. Castro, Jinwoo Cheon, Jae-Hyun Lee*, and Hakho Lee* († equally contributed)
  Adv. Sci., 10 (10), 2206872

  CRISPR/Cas systems offer a powerful sensing mechanism to transduce sequence-specific information int...

• [Precision Nanomedicine]   Dec 1, 2022
  Adherens Junctions Organize Size-Selective Proteolytic Hotspots Critical for Notch Signalling
  Minsuk Kwak†, Kaden M. Southard†, Woon Ryoung Kim†, Annie Lin, Nam Hyeong Kim, Ramu Gopalappa, Hyun Jung Lee, Minji An, Seo Hyun Choi, Yunmin Jung, Kunwoo Noh, Justin Farlow, Anastasios Georgakopoulos, Nikolaos K. Robakis, Min K. Kang, Matthew L. Kutys, Daeha Seo, Hyongbum Henry Kim, Yong Ho Kim, Jinwoo Cheon, Zev J. Gartner*, and Young-wook Jun* († equally contributed)
  Nat. Cell Biol., 24, 1739–1753

  Adherens junctions (AJs) create spatially, chemically and mechanically discrete microdomains at cell...

• [Precision Nanomedicine]   Sep 7, 2022
  Magnetogenetics with Piezo1 Mechanosensitive Ion Channel for CRISPR Gene Editing
  Wookjin Shin†, Sumin Jeong†, Jung-uk Lee, Soo Yeun Jeong, Jeonghong Shin, Hyongbum Henry Kim*, Jinwoo Cheon*, and Jae-Hyun Lee *(† equally contributed)
  Nano Lett., 22 (18), 7415–7422

  Regulation of genetic activity in single cells and tissues is pivotal to determine key cellular func...

• [Evolutionary Nanomaterials]   Mar 17, 2022
  Binary-State Scanning Probe Microscopy for Parallel Imaging
  Gwangmook Kim, Eoh Jin Kim, Hyung Wan Do, Min-Kyun Cho, Sungsoon Kim, Shinill Kang, Dohun Kim, Jinwoo Cheon, and Wooyoung Shim*
  Nat. Commun., 13, 1438

  Scanning probe microscopy techniques, such as atomic force microscopy and scanning tunnelling micros...

• [Precision Nanomedicine]   Oct 20, 2021
  A Rapid Assay Provides On-Site Quantification of Tetrahydrocannabinol in Oral Fluid
  Hojeong Yu, Hoyeon Lee, Jiyong Cheong, Sang Won Woo, Juhyun Oh, Hyun-kyung Oh, Jae-Hyun Lee, Hui Zheng, Cesar M. Castro, Yeong-Eun Yoo, Min-Gon Kim, Jinwoo Cheon, Ralph Weissleder, and Hakho Lee*
  Sci. Transl. Med., 13 (616), 1-10

  Tetrahydrocannabinol (THC), the primary psychoactive ingredient of cannabis, impairs cognitive and m...

• [Evolutionary Nanomaterials]   Apr 15, 2021
  Magnetothermally Activated Nanometer-level Modular Functional Group Grafting of Nanoparticles
  Yongjun Lim, Seung-hyun Noh, Tae-Hyun Shin, Jung-uk Lee, Dominik Lungerich, Jae-Hyun Lee, and Jinwoo Cheon*
  Nano Lett., 21 (8), 3649–3656

  Nanoparticles with multifunctionality and high colloidal stability are essential for biomedical appl...

• [Precision Nanomedicine]   Mar 8, 2021
  High-Resolution T1 MRI via Renally Clearable Dextran Nanoparticles with an Iron Oxide Shell
  Tae-Hyun Shin†, Pan Ki Kim†, Sunghwi Kang, Jiyong Cheong, Soojin Kim, Yongjun Lim, Wookjin Shin, Joon-Yong Jung, Jungsu D. Lah, Byoung Wook Choi*, and Jinwoo Cheon* († equally contributed)
  Nat. Biomed. Eng., 5 (3), 252-263

  Contrast agents for magnetic resonance imaging (MRI) improve anatomical visualizations. However, owi...

• [Precision Nanomedicine]   Jan 28, 2021
  Non-Contact Long-Range Magnetic Stimulation of Mechanosensitive Ion Channels in Freely Moving Animals
  Jung-uk Lee, Wookjin Shin, Yongjun Lim, Jungsil Kim, Woon Ryoung Kim, Heehun Kim, Jae-Hyun Lee, and Jinwoo Cheon*
  Nat. Mater., 20 (7), 1029–1036

  Among physical stimulation modalities, magnetism has clear advantages, such as deep penetration and ...

List