Yonsei Advanced Science Institute

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Research Highlights

• [Precision Nanomedicine]   Jul 2, 2024
  In Vivo Magnetogenetics for Cell-Type-Specific Targeting and Modulation of Brain Circuits
  Seo-Hyun Choi, Jihye Shin, Chanhyun Park, Jung-uk Lee, Jaegyeong Lee, Yuko Ambo, Wookjin Shin, Ri Yu, Ju-Young Kim, Jungsu David Lah, Donghun Shin, Gooreum Kim, Kunwoo Noh, Wuhyun Koh, C. Justin Lee, Jae-Hyun Lee*, Minsuk Kwak*, and Jinwoo Cheon*
  Nat. Nanotechnol., 19, 1333–1343

  Neuromodulation technologies are crucial for investigating neuronal connectivity and brain function....

• [Evolutionary Nanomaterials]   Aug 28, 2024
  Cation-Eutaxy-Enabled III–V-Derived Van Der Waals Crystals as Memristive Semiconductors
  Jihong Bae†, Jongbum Won†, Taeyoung Kim, Sangjin Choi, Hyesoo Kim, Seung-Hyun Victor Oh, Giyeok Lee, Eunsil Lee, ..., Jae-Hyun Lee, Heejun Yang, Yunseok Kim, Hong-Gyu Park, Wooyoung Lee, Kee Joo Chang, Miso Kim, Dong Won Chun, Myung Joon Han, Aron Walsh, Aloysius Soon*, Jinwoo Cheon*, Cheolmin Park*, Jong-Young Kim*, and Wooyoung Shim* († equally contributed)
  Nat. Mater., 23, 1402–1410

  Novel two-dimensional semiconductor crystals can exhibit diverse physical properties beyond their in...

• [Nanobio Interface]   Feb 27, 2024
  In-Vivo Integration of Soft Neural Probes Through High-Resolution Printing of Liquid Electronics on the Cranium
  Young-Geun Park†, Yong Won Kwon†, Chin Su Koh†, Enji Kim†, Dong Ha Lee, Sumin Kim, Jongmin Mun, Yeon-Mi Hong, Sanghoon Lee, Ju-Young Kim, Jae-Hyun Lee, Hyun Ho Jung*, Jinwoo Cheon*, Jin Woo Chang*, and Jang-Ung Park* († equally contributed)
  Nat. Commun., 15, 1772

  Current soft neural probes are still operated by bulky, rigid electronics mounted to a body, which d...

• [Evolutionary Nanomaterials]   Feb 7, 2024
  A Magnetically Powered Nanomachine with a DNA Clutch
  Mouhong Lin, Jung-uk Lee, Youngjoo Kim, Gooreum Kim, Yunmin Jung, Ala Jo, Mansoo Park, Sol Lee, Jungsu David Lah, Jongseong Park, Kunwoo Noh, Jae-Hyun Lee, Minsuk Kwak, Dominik Lungerich*, and Jinwoo Cheon*
  Nat. Nanotechnol., 19, 646–651

  Measuring cellular and tissue mechanics inside intact living organisms is essential for interrogatin...

• [Nanobio Interface]   Dec 29, 2023
  Nanoscale Magneto-mechanical-genetics of Deep Brain Neurons Reversing Motor Deficits in Parkinsonian Mice
  Wookjin Shin, Yeongdo Lee, Jueun Lim, Youbin Lee, Jungsu David Lah, Somin Lee, Jung-uk Lee, Ri Yu, Phil Hyu Lee, Jae-Hyun Lee, Minsuk Kwak*, and Jinwoo Cheon*
  Nano Lett., 24 (1), 270–278

  Here, we introduce the magneto-mechanical-genetic (MMG)-driven wireless deep brain stimulation (DBS)...

• [Nanobio Interface]   Oct 16, 2023
  Magneto-Acoustic Protein Nanostructures for Non-Invasive Imaging of Tissue Mechanics In Vivo
  Whee-Soo Kim†, Sungjin Min†, Su Kyeom Kim, Sunghwi Kang, Soohwan An, Ernesto Criado-Hidalgo, Hunter Davis, Avinoam Bar-Zion, Dina Malounda, Yu Heun Kim, Jae-Hyun Lee, Soo Han Bae, Jin Gu Lee, Minsuk Kwak, Seung-Woo Cho*, Mikhail G. Shapiro*, and Jinwoo Cheon* († equally contributed)
  Nat. Mater., 23, 290–300

  Measuring cellular and tissue mechanics inside intact living organisms is essential for interrogatin...

• [Precision Nanomedicine]   Jul 23, 2023
  Inaugurating High-Throughput Profiling of Extracellular Vesicles for Earlier Ovarian Cancer Detection
  Ala Jo, Allen Green, Jamie E. Medina, Sonia Iyer, Anders W. Ohman, Eric T. McCarthy, Ferenc Reinhardt, Thomas Gerton, Daniel Demehin, Ranjan Mishra, David L. Kolin, Hui Zheng, Jinwoo Cheon, Christopher P. Crum, Robert A. Weinberg, Bo R. Rueda, Cesar M. Castro*, Daniela M. Dinulescu*, and Hakho Lee*
  Adv. Sci, 10 (27), 2301930

  Detecting early cancer through liquid biopsy is challenging due to the lack of specific biomarkers f...

• [Nanobio Interface]   May 16, 2023
  Hydrogel Magnetomechanical Actuator Nanoparticles for Wireless Remote Control of Mechanosignaling In Vivo
  Sumin Jeong†, Wookjin Shin†, Mansoo Park, Jung-uk Lee, Yongjun Lim, Kunwoo Noh, Jae-Hyun Lee, Young-wook Jun*, Minsuk Kwak*, and Jinwoo Cheon* († equally contributed)
  Nano Lett., 17 (11), 9919–9937

  As a new enabling nanotechnology tool for wireless, target-specific, and long-distance stimulation o...

• [Precision Nanomedicine]   Feb 1, 2023
  CRISPR-Enhanced Hydrogel Microparticles for Multiplexed Detection of Nucleic Acids
  Yoon Ho Roh†, Chang Yeol Lee†, Sujin Lee, Hyunho Kim, Amy Ly, Cesar M. Castro, Jinwoo Cheon, Jae-Hyun Lee*, and Hakho Lee* († equally contributed)
  Adv. Sci., 10 (10), 2206872

  CRISPR/Cas systems offer a powerful sensing mechanism to transduce sequence-specific information int...

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