- [Precision Nanomedicine] Jul 2, 2024
In Vivo Magnetogenetics for Cell-Type-Specific Targeting and Modulation of Brain Circuits
Seo-Hyun Choi, Jihye Shin, Chanhyun Park, Jung-uk Lee, Jaegyeong Lee, Yuko Ambo, Wookjin Shin, Ri Yu, Ju-Young Kim, Jungsu David Lah, Donghun Shin, Gooreum Kim, Kunwoo Noh, Wuhyun Koh, C. Justin Lee, Jae-Hyun Lee*, Minsuk Kwak*, and Jinwoo Cheon*
Nat. Nanotechnol., online publishedNeuromodulation technologies are crucial for investigating neuronal connectivity and brain function....
- [Nanobio Interface] Feb 27, 2024
In-vivo Integration of Soft Neural Probes Through High-Resolution Printing of Liquid Electronics on the Cranium
Young-Geun Park†, Yong Won Kwon†, Chin Su Koh†, Enji Kim†, Dong Ha Lee, Sumin Kim, Jongmin Mun, Yeon-Mi Hong, Sanghoon Lee, Ju-Young Kim, Jae-Hyun Lee, Hyun Ho Jung*, Jinwoo Cheon*, Jin Woo Chang*, and Jang-Ung Park* († equally contributed)
Nat. Commun., 15, 1772Current soft neural probes are still operated by bulky, rigid electronics mounted to a body, which d...
- [Evolutionary Nanomaterials] Feb 7, 2024
A Magnetically Powered Nanomachine with a DNA Clutch
Mouhong Lin, Jung-uk Lee, Youngjoo Kim, Gooreum Kim, Yunmin Jung, Ala Jo, Mansoo Park, Sol Lee, Jungsu David Lah, Jongseong Park, Kunwoo Noh, Jae-Hyun Lee, Minsuk Kwak, Dominik Lungerich*, and Jinwoo Cheon*
Nat. Nanotechnol., 19, 646–651Measuring cellular and tissue mechanics inside intact living organisms is essential for interrogatin...
- [Nanobio Interface] Dec 29, 2023
Nanoscale Magneto-mechanical-genetics of Deep Brain Neurons Reversing Motor Deficits in Parkinsonian Mice
Wookjin Shin, Yeongdo Lee, Jueun Lim, Youbin Lee, Jungsu David Lah, Somin Lee, Jung-uk Lee, Ri Yu, Phil Hyu Lee, Jae-Hyun Lee, Minsuk Kwak*, and Jinwoo Cheon*
Nano Lett., 24 (1), 270–278Here, we introduce the magneto-mechanical-genetic (MMG)-driven wireless deep brain stimulation (DBS)...
- [Nanobio Interface] Oct 16, 2023
Magneto-Acoustic Protein Nanostructures for Non-Invasive Imaging of Tissue Mechanics In Vivo
Whee-Soo Kim†, Sungjin Min†, Su Kyeom Kim, Sunghwi Kang, Soohwan An, Ernesto Criado-Hidalgo, Hunter Davis, Avinoam Bar-Zion, Dina Malounda, Yu Heun Kim, Jae-Hyun Lee, Soo Han Bae, Jin Gu Lee, Minsuk Kwak, Seung-Woo Cho*, Mikhail G. Shapiro*, and Jinwoo Cheon* († equally contributed)
Nat. Mater., 23, 290–300Measuring cellular and tissue mechanics inside intact living organisms is essential for interrogatin...
- [Precision Nanomedicine] Jul 23, 2023
Inaugurating High-Throughput Profiling of Extracellular Vesicles for Earlier Ovarian Cancer Detection
Ala Jo, Allen Green, Jamie E. Medina, Sonia Iyer, Anders W. Ohman, Eric T. McCarthy, Ferenc Reinhardt, Thomas Gerton, Daniel Demehin, Ranjan Mishra, David L. Kolin, Hui Zheng, Jinwoo Cheon, Christopher P. Crum, Robert A. Weinberg, Bo R. Rueda, Cesar M. Castro*, Daniela M. Dinulescu*, and Hakho Lee*
Adv. Sci, 10 (27), 2301930Detecting early cancer through liquid biopsy is challenging due to the lack of specific biomarkers f...
- [Nanobio Interface] May 16, 2023
Hydrogel Magnetomechanical Actuator Nanoparticles for Wireless Remote Control of Mechanosignaling In Vivo
Sumin Jeong†, Wookjin Shin†, Mansoo Park, Jung-uk Lee, Yongjun Lim, Kunwoo Noh, Jae-Hyun Lee, Young-wook Jun*, Minsuk Kwak*, and Jinwoo Cheon* († equally contributed)
Nano Lett., 17 (11), 9919–9937As a new enabling nanotechnology tool for wireless, target-specific, and long-distance stimulation o...
- [Precision Nanomedicine] Feb 1, 2023
CRISPR-Enhanced Hydrogel Microparticles for Multiplexed Detection of Nucleic Acids
Yoon Ho Roh†, Chang Yeol Lee†, Sujin Lee, Hyunho Kim, Amy Ly, Cesar M. Castro, Jinwoo Cheon, Jae-Hyun Lee*, and Hakho Lee* († equally contributed)
Adv. Sci., 10 (10), 2206872CRISPR/Cas systems offer a powerful sensing mechanism to transduce sequence-specific information int...
- [Precision Nanomedicine] Dec 1, 2022
Adherens Junctions Organize Size-Selective Proteolytic Hotspots Critical for Notch Signaling
Minsuk Kwak†, Kaden M. Southard†, Woon Ryoung Kim†, Annie Lin, Nam Hyeong Kim, Ramu Gopalappa, Hyun Jung Lee, Minji An, Seo Hyun Choi, Yunmin Jung, Kunwoo Noh, Justin Farlow, Anastasios Georgakopoulos, Nikolaos K. Robakis, Min K. Kang, Matthew L. Kutys, Daeha Seo, Hyongbum Henry Kim, Yong Ho Kim, Jinwoo Cheon, Zev J. Gartner*, and Young-wook Jun* († equally contributed)
Nat. Cell Biol., 24, 1739–1753Adherens junctions (AJs) create spatially, chemically and mechanically discrete microdomains at cell...