- [Precision Nanomedicine] Feb 1, 2023
CRISPR-Enhanced Hydrogel Microparticles for Multiplexed Detection of Nucleic Acids
Yoon Ho Roh†, Chang Yeol Lee†, Sujin Lee, Hyunho Kim, Amy Ly, Cesar M. Castro, Jinwoo Cheon, Jae-Hyun Lee*, and Hakho Lee* († equally contributed)
Adv. Sci., online published, 2206872
CRISPR/Cas systems offer a powerful sensing mechanism to transduce sequence-specific information int...
- [Precision Nanomedicine] Dec 1, 2022
Adherens Junctions Organize Size-Selective Proteolytic Hotspots Critical for Notch Signalling
Minsuk Kwak†, Kaden M. Southard†, Woon Ryoung Kim†, Annie Lin, Nam Hyeong Kim, Ramu Gopalappa, Hyun Jung Lee, Minji An, Seo Hyun Choi, Yunmin Jung, Kunwoo Noh, Justin Farlow, Anastasios Georgakopoulos, Nikolaos K. Robakis, Min K. Kang, Matthew L. Kutys, Daeha Seo, Hyongbum Henry Kim, Yong Ho Kim, Jinwoo Cheon, Zev J. Gartner*, and Young-wook Jun* († equally contributed)
Nat. Cell Biol., 24, 1739–1753
Adherens junctions (AJs) create spatially, chemically and mechanically discrete microdomains at cell...
- [Precision Nanomedicine] Sep 7, 2022
Magnetogenetics with Piezo1 Mechanosensitive Ion Channel for CRISPR Gene Editing
Wookjin Shin†, Sumin Jeong†, Jung-uk Lee, Soo Yeun Jeong, Jeonghong Shin, Hyongbum Henry Kim*, Jinwoo Cheon*, and Jae-Hyun Lee *(† equally contributed)
Nano Lett., 22 (18), 7415–7422
Regulation of genetic activity in single cells and tissues is pivotal to determine key cellular func...
- [Evolutionary Nanomaterials] Mar 17, 2022
Binary-State Scanning Probe Microscopy for Parallel Imaging
Gwangmook Kim, Eoh Jin Kim, Hyung Wan Do, Min-Kyun Cho, Sungsoon Kim, Shinill Kang, Dohun Kim, Jinwoo Cheon, and Wooyoung Shim*
Nat. Commun., 13, 1438
Scanning probe microscopy techniques, such as atomic force microscopy and scanning tunnelling micros...
- [Precision Nanomedicine] Oct 20, 2021
A Rapid Assay Provides On-Site Quantification of Tetrahydrocannabinol in Oral Fluid
Hojeong Yu, Hoyeon Lee, Jiyong Cheong, Sang Won Woo, Juhyun Oh, Hyun-kyung Oh, Jae-Hyun Lee, Hui Zheng, Cesar M. Castro, Yeong-Eun Yoo, Min-Gon Kim, Jinwoo Cheon, Ralph Weissleder, and Hakho Lee*
Sci. Transl. Med., 13 (616), 1-10
Tetrahydrocannabinol (THC), the primary psychoactive ingredient of cannabis, impairs cognitive and m...
- [Evolutionary Nanomaterials] Apr 15, 2021
Magnetothermally Activated Nanometer-level Modular Functional Group Grafting of Nanoparticles
Yongjun Lim, Seung-hyun Noh, Tae-Hyun Shin, Jung-uk Lee, Dominik Lungerich, Jae-Hyun Lee, and Jinwoo Cheon*
Nano Lett., 21 (8), 3649–3656
Nanoparticles with multifunctionality and high colloidal stability are essential for biomedical appl...
- [Precision Nanomedicine] Mar 8, 2021
High-Resolution T1 MRI via Renally Clearable Dextran Nanoparticles with an Iron Oxide Shell
Tae-Hyun Shin†, Pan Ki Kim†, Sunghwi Kang, Jiyong Cheong, Soojin Kim, Yongjun Lim, Wookjin Shin, Joon-Yong Jung, Jungsu D. Lah, Byoung Wook Choi*, and Jinwoo Cheon* († equally contributed)
Nat. Biomed. Eng., 5 (3), 252-263
Contrast agents for magnetic resonance imaging (MRI) improve anatomical visualizations. However, owi...
- [Precision Nanomedicine] Jan 28, 2021
Non-Contact Long-Range Magnetic Stimulation of Mechanosensitive Ion Channels in Freely Moving Animals
Jung-uk Lee, Wookjin Shin, Yongjun Lim, Jungsil Kim, Woon Ryoung Kim, Heehun Kim, Jae-Hyun Lee, and Jinwoo Cheon*
Nat. Mater., 20 (7), 1029–1036
Among physical stimulation modalities, magnetism has clear advantages, such as deep penetration and ...
- [Precision Nanomedicine] Dec 3, 2020
Fast Detection of SARS-CoV-2 RNA via the Integration of Plasmonic Thermocycling and Fluorescence Detection in a Portable Device
Jiyong Cheong†, Hojeong Yu†, Chang Yeol Lee, Jung-uk Lee, Hyun-jung Choi, Jae-Hyun Lee*, Hakho Lee*, and Jinwoo Cheon* († equally contributed)
Nat. Biomed. Eng., 4, 1159–1167
The diagnosis of severe acute respiratory syndrome 2 (SARS-CoV-2) infection by quantitative PCR with...