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Jae-Hyun Lee†, Kyuri Lee†, Seung Ho Moon, Yuhan Lee, Tae Gwan Park*, and Jinwoo Cheon* († equally contributed)
All-in-one Target-Cell-Specific Magnetic Nanoparticles for Simultaneous Molecular Imaging and siRNA Delivery
Angew. Chem. Int. Ed., 48 (23), 4174-4179
All-in-one Target-Cell-Specific Magnetic Nanoparticles for Simultaneous Molecular Imaging and siRNA Delivery
Angew. Chem. Int. Ed., 48 (23), 4174-4179
Date: May 25, 2009
Cancer‐cell‐targeted gene silencing was observed with a magnetic‐nanoparticle platform (MEIO, magnetism‐engineered iron oxide) on which a fluorescent dye, siRNA, and a RGD‐peptide targeting moiety were attached (see picture). The different functionalities enable the macroscopic (magnetic resonance) and microscopic (fluorescence) imaging of target cells. This system may be suitable for concurrent diagnostic and therapeutic applications.
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