Yonsei Advanced Science Institute

JC: Although I am an inorganic chemist by training, I became intrigued by nanoparticle chemistry in the mid-1990s. Hence, since the launch of my independent career in 1998, my expertise has evolved from the shape control of nanoparticles over the past quarter century to nanoparticle bioimaging and, now, nanomedicine. To elaborate further on that development, the understanding of the synthetic approaches of shape-controlled nanoparticles and associated phenomena was a key project of my research lab in the late 1990s and early 2000s. One of the most significant catalytic moments came upon conversing with biologists; my interest shifted and became much more concentrated on molecular-level interfacing of nanomaterials for imaging and actuation of biological systems. Since nanomaterials and devices are in similar sizes in the functional units of biological systems, such as genes and proteins, it was obvious that the roles and impacts of nanomaterials and devices would be significant. However, we have yet to utilize those advantages, which comprise the potential for powerful field advances. With the spatiotemporally seamless integration and communicative feedback systems between the nanomaterials based on the physical world and the counterparts of the biological world, we could envision enormous advances in resolving some of the biggest challenges of human health.

 

CM: What is your research specialty and what inspired you to study and conduct research in this area?

JC: I see innovative nanomaterials systems as key to success for future medicine. It is clear that our understanding of biological systems lags behind our desired level of knowledge, and the need for precise nanoscale tools and methodologies is critical to interrogating complex biological systems. The use of molecular-level interfacing and utilization of nanomaterials and devices for biological systems is on the horizon. However, spatiotemporally precise and holistic measurement and actuation of complex biological systems such as brain circuits and deep tissue organs are still in the premature stages, and the delivery of desired cargo to the targeted areas has yet to be effective. My main focus lies in nanomaterials and their potential to facilitate molecular imaging and actuation of targets located deep inside the body, otherwise inaccessible by optical systems. Magnetic and sonic modalities could be attractive, but there are significant challenges in developing new concepts and innovative nanomaterials and tools that are effective. In such endeavors, we are slowly making exciting advances by collaborating with bioengineers, neuroscientists, and immunologists to achieve promising outcomes that will be vital for the nanomedicine of the future.

 

CM: What do you see as a grand challenge in the field of materials and what would help the community address this challenge?

JC: Chemistry has come a long way, expanding its scope from molecular chemistry to materials chemistry, nanoscience, and beyond. It is now playing significant roles in energy, environment, and health. However, our challenges in these areas are becoming increasingly difficult to bear. As such, continued scientific breakthroughs are essential, and the public should be well-informed about the current issues to gain a better understanding of the science behind them. Teaching in classrooms and outreach programs designed to educate young and adult generations is essential.

 

CM: What words of inspiration do you have to share with the readers of Chemistry of Materials?