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Jae Chul Hwang†, Moohyun Kim†, Sumin Kim, Hunkyu Seo, Soohwan An, Eui Hwa Jang, Seung Yeop Han, Mi Jung Kim, Nam Kyun Kim, Seung-Woo Cho*, Sak Lee*, and Jang-Ung Park* († equally contributed)
In situ Diagnosis and Simultaneous Treatment of Cardiac Diseases using a Single-device Platform
Sci. Adv., 8 (37), 1-16
Date: Sep 14, 2022

The in situ diagnosis of cardiac activities with simultaneous therapeutic electrical stimulation of the heart is key to preventing cardiac arrhythmia. Here, we present an unconventional single-device platform that enables in situ monitoring even in a wet condition and control of beating heart motions without interferences to the recording signal. This platform consists of the active-matrix array of pressure-sensitive transistors for detecting cardiac beatings, biocompatible, low-impedance electrodes for cardiac stimulations, and an alginate-based hydrogel adhesive for attaching this platform conformally to the epicardium. In contrast to conventional electrophysiological sensing using electrodes, the pressure-sensitive transistors measured mechanophysiological characteristics by monitoring the spatiotemporal distributions of cardiac pressures during heart beating motions. In vivo tests show mechanophysiological readings having good correlation with electrocardiography and negligible interference with the electrical artifacts caused during cardiac stimulations. This platform can therapeutically synchronize the rhythm of abnormal heartbeats through efficient pacing of cardiac arrhythmia.

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